| 1. Round | 07/08/2021 | Northampton Town | - | Port Vale FC | 1:0 | ||||
| 20. Round | 07/12/2021 | Bristol Rovers | - | Port Vale FC | 1:2 | ||||
| 27. Round | 15/01/2022 | Port Vale FC | - | Swindon Town | 1:3 | ||||
| 23. Round | 18/01/2022 | Port Vale FC | - | Salford City | 0:1 | ||||
| 28. Round | 22/01/2022 | Leyton Orient | - | Port Vale FC | 0:0 | ||||
| 36. Round | 12/03/2022 | Port Vale FC | - | Crawley Town | 4:1 | ||||
| 37. Round | 15/03/2022 | Port Vale FC | - | Mansfield Town | 3:1 |  |
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| 38. Round | 19/03/2022 | Bradford City | - | Port Vale FC | 1:2 | ||||
| 22. Round | 22/03/2022 | Port Vale FC | - | Exeter City | 0:0 | ||||
| 39. Round | 26/03/2022 | Port Vale FC | - | Sutton United | 2:0 | ||||
| 40. Round | 02/04/2022 | Barrow AFC | - | Port Vale FC | 1:2 | ||||
| 30. Round | 05/04/2022 | Salford City | - | Port Vale FC | 0:1 | ||||
| 41. Round | 09/04/2022 | Port Vale FC | - | Oldham Athletic | 3:2 | |
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| 42. Round | 15/04/2022 | Hartlepool United | - | Port Vale FC | 0:1 | ||||
| 43. Round | 18/04/2022 | Port Vale FC | - | Bristol Rovers | 1:3 | ||||
| 44. Round | 23/04/2022 | Walsall FC | - | Port Vale FC | 2:0 | ||||
| 45. Round | 02/05/2022 | Port Vale FC | - | Newport County | 1:2 | ||||
| 46. Round | 07/05/2022 | Exeter City | - | Port Vale FC | 0:1 | |
England