| 1. Round | 07/08/2010 | Crewe Alexandra | - | Hereford United | 0:1 | ||||
| 3. Round | 21/08/2010 | Crewe Alexandra | - | Barnet FC | 7:0 |  |
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| 9. Round | 28/09/2010 | Crewe Alexandra | - | Macclesfield Town | 1:1 | |
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| 10. Round | 02/10/2010 | Chesterfield FC | - | Crewe Alexandra | 5:5 | ||||
| 11. Round | 09/10/2010 | Crewe Alexandra | - | Torquay United | 3:3 | ||||
| 15. Round | 02/11/2010 | Crewe Alexandra | - | Shrewsbury Town | 1:2 | ||||
| 28. Round | 22/01/2011 | Aldershot Town | - | Crewe Alexandra | 3:2 | ||||
| 30. Round | 01/02/2011 | Northampton Town | - | Crewe Alexandra | 6:2 | |
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| 31. Round | 05/02/2011 | Rotherham United | - | Crewe Alexandra | 3:1 | |
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| 32. Round | 12/02/2011 | Crewe Alexandra | - | Gillingham FC | 1:1 | ||||
| 33. Round | 19/02/2011 | Crewe Alexandra | - | Stevenage FC | 0:1 | ||||
| 34. Round | 26/02/2011 | Bury FC | - | Crewe Alexandra | 3:1 | ||||
| 35. Round | 05/03/2011 | Crewe Alexandra | - | Burton Albion | 4:1 | ||||
| 36. Round | 08/03/2011 | Macclesfield Town | - | Crewe Alexandra | 1:0 | ||||
| 38. Round | 19/03/2011 | Oxford United | - | Crewe Alexandra | 2:1 | |
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| 29. Round | 22/03/2011 | Crewe Alexandra | - | Accrington Stanley | 0:0 |
England