1. Round 07/08/2021 Carlisle United - Colchester United 0:0
2. Round 14/08/2021 Colchester United - Northampton Town 0:1
3. Round 17/08/2021 Colchester United - Mansfield Town 1:1
4. Round 21/08/2021 Oldham Athletic - Colchester United 1:2
7. Round 10/09/2021 Barrow AFC - Colchester United 2:3 Goal yellow card
8. Round 18/09/2021 Colchester United - Crawley Town 0:1
9. Round 25/09/2021 Swindon Town - Colchester United 0:0
10. Round 02/10/2021 Colchester United - Salford City 0:2
11. Round 08/10/2021 Tranmere Rovers - Colchester United 2:0
19. Round 26/11/2021 Colchester United - Newport County 1:1
20. Round 08/12/2021 Bradford City - Colchester United 0:0
21. Round 11/12/2021 Walsall FC - Colchester United 3:0
25. Round 01/01/2022 Crawley Town - Colchester United 3:1
16. Round 11/01/2022 Forest Green Rovers - Colchester United 2:0
27. Round 15/01/2022 Colchester United - Barrow AFC 0:2
28. Round 22/01/2022 Salford City - Colchester United 0:3
29. Round 29/01/2022 Colchester United - Swindon Town 1:1
26. Round 01/02/2022 Colchester United - Rochdale AFC 1:1 Goal
31. Round 08/02/2022 Mansfield Town - Colchester United 2:1 Goal
32. Round 12/02/2022 Colchester United - Carlisle United 2:2
33. Round 19/02/2022 Northampton Town - Colchester United 3:0 yellow card
22. Round 22/02/2022 Colchester United - Hartlepool United 1:2
34. Round 26/02/2022 Colchester United - Oldham Athletic 1:1
23. Round 01/03/2022 Colchester United - Leyton Orient 2:2 yellow card
39. Round 26/03/2022 Colchester United - Tranmere Rovers 1:0
40. Round 02/04/2022 Harrogate Town - Colchester United 1:2
41. Round 09/04/2022 Colchester United - Stevenage FC 0:2
42. Round 15/04/2022 Exeter City - Colchester United 2:0
43. Round 18/04/2022 Colchester United - Bradford City 3:0
44. Round 22/04/2022 Newport County - Colchester United 1:2
45. Round 30/04/2022 Colchester United - Walsall FC 2:2
46. Round 07/05/2022 Hartlepool United - Colchester United 0:2