| 6. Round | 04/09/2021 | Stevenage FC | - | Swindon Town | 1:1 | ||||
| 7. Round | 11/09/2021 | Swindon Town | - | Port Vale FC | 1:2 |  |
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| 8. Round | 18/09/2021 | Northampton Town | - | Swindon Town | 1:1 | ||||
| 9. Round | 25/09/2021 | Swindon Town | - | Colchester United | 0:0 | ||||
| 10. Round | 02/10/2021 | Bristol Rovers | - | Swindon Town | 1:3 | ||||
| 14. Round | 23/10/2021 | Swindon Town | - | Bradford City | 1:3 | ||||
| 17. Round | 20/11/2021 | Newport County | - | Swindon Town | 1:2 | ||||
| 21. Round | 11/12/2021 | Barrow AFC | - | Swindon Town | 2:0 |
England