| 28. Round | 22/01/2022 | Harrogate Town | - | Oldham Athletic | 3:0 | ||||
| 29. Round | 29/01/2022 | Oldham Athletic | - | Rochdale AFC | 0:0 |  |
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| 31. Round | 08/02/2022 | Oldham Athletic | - | Bristol Rovers | 2:1 | ||||
| 33. Round | 19/02/2022 | Oldham Athletic | - | Bradford City | 2:0 | ||||
| 34. Round | 26/02/2022 | Colchester United | - | Oldham Athletic | 1:1 | ||||
| 35. Round | 05/03/2022 | Oldham Athletic | - | Carlisle United | 1:2 | ||||
| 37. Round | 15/03/2022 | Walsall FC | - | Oldham Athletic | 2:1 | ||||
| 38. Round | 19/03/2022 | Oldham Athletic | - | Exeter City | 0:2 | ||||
| 26. Round | 22/03/2022 | Oldham Athletic | - | Sutton United | 1:3 | ||||
| 39. Round | 26/03/2022 | Oldham Athletic | - | Mansfield Town | 1:2 | ||||
| 27. Round | 29/03/2022 | Oldham Athletic | - | Leyton Orient | 2:0 | ||||
| 42. Round | 15/04/2022 | Oldham Athletic | - | Northampton Town | 0:2 | ||||
| 45. Round | 30/04/2022 | Tranmere Rovers | - | Oldham Athletic | 2:0 |
England
Ireland