| 1. Round | 07/08/2021 | Scunthorpe United | - | Swindon Town | 1:3 | ||||
| 2. Round | 14/08/2021 | Rochdale AFC | - | Scunthorpe United | 0:0 | ||||
| 16. Round | 13/11/2021 | Scunthorpe United | - | Salford City | 1:1 |  |
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| 17. Round | 20/11/2021 | Mansfield Town | - | Scunthorpe United | 3:1 | ||||
| 18. Round | 23/11/2021 | Scunthorpe United | - | Leyton Orient | 1:1 | ||||
| 19. Round | 27/11/2021 | Scunthorpe United | - | Bradford City | 1:1 | ||||
| 23. Round | 26/12/2021 | Oldham Athletic | - | Scunthorpe United | 1:3 |
England