| 1. Round | 15/08/2022 | Real Betis | - | Elche CF | 3:0 | ||||
| 2. Round | 20/08/2022 | RCD Mallorca | - | Real Betis | 1:2 | ||||
| 3. Round | 26/08/2022 | Real Betis | - | CA Osasuna | 1:0 | ||||
| 4. Round | 03/09/2022 | Real Madrid | - | Real Betis | 2:1 | ||||
| 5. Round | 11/09/2022 | Real Betis | - | Villarreal CF | 1:0 | ||||
| 6. Round | 18/09/2022 | Real Betis | - | Girona FC | 2:1 | ||||
| 7. Round | 02/10/2022 | RC Celta | - | Real Betis | 1:0 | ||||
| 8. Round | 09/10/2022 | Real Valladolid | - | Real Betis | 0:0 | ||||
| 9. Round | 16/10/2022 | Real Betis | - | UD Almería | 3:1 | ||||
| 11. Round | 23/10/2022 | Real Betis | - | Atlético Madrid | 1:2 | ||||
| 12. Round | 30/10/2022 | Real Sociedad | - | Real Betis | 0:2 | ||||
| 13. Round | 06/11/2022 | Real Betis | - | Sevilla FC | 1:1 |  |
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| 14. Round | 10/11/2022 | Valencia CF | - | Real Betis | 3:0 | ||||
| 15. Round | 29/12/2022 | Real Betis | - | Athletic Club | 0:0 | ||||
| 16. Round | 08/01/2023 | Rayo Vallecano | - | Real Betis | 1:2 |
Spain