| 11. Round | 11/06/2021 | Galway United | - | Athlone Town | 2:1 | ||||
| 12. Round | 18/06/2021 | Galway United | - | Cabinteely FC | 1:0 | ||||
| 14. Round | 02/07/2021 | UC Dublin | - | Galway United | 0:2 | ||||
| 15. Round | 09/07/2021 | Galway United | - | Cobh Ramblers | 2:0 | ||||
| 17. Round | 30/07/2021 | Wexford FC | - | Galway United | 1:3 | ||||
| 21. Round | 03/09/2021 | Cabinteely FC | - | Galway United | 0:1 | ||||
| 23. Round | 24/09/2021 | Galway United | - | UC Dublin | 4:1 | ||||
| 26. Round | 15/10/2021 | Galway United | - | Wexford FC | 2:1 | ||||
| 25. Round | 22/10/2021 | Galway United | - | Bray Wanderers | 1:0 | ||||
| 27. Round | 29/10/2021 | Cork City | - | Galway United | 3:0 |
Ireland