| 14. Round | 11/01/2016 | Southampton FC U21 | - | Liverpool FC U21 | 1:2 | ||||
| 7. Round | 18/01/2016 | Manchester United U21 | - | Southampton FC U21 | 4:0 | ||||
| 17. Round | 09/02/2016 | Southampton FC U21 | - | Tottenham Hotspur U21 | 1:1 | ||||
| 15. Round | 15/02/2016 | Everton FC U21 | - | Southampton FC U21 | 3:1 | ||||
| 18. Round | 22/02/2016 | Southampton FC U21 | - | Reading FC U21 | 1:1 | ||||
| 12. Round | 29/02/2016 | Southampton FC U21 | - | Chelsea FC U21 | 0:0 |  |
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| 19. Round | 07/03/2016 | Leicester City U21 | - | Southampton FC U21 | 2:1 | ||||
| 20. Round | 14/03/2016 | Middlesbrough FC U21 | - | Southampton FC U21 | 1:3 | ||||
| 9. Round | 20/03/2016 | Liverpool FC U21 | - | Southampton FC U21 | 0:5 | ||||
| 21. Round | 03/04/2016 | Sunderland AFC U21 | - | Southampton FC U21 | 2:2 | ||||
| 16. Round | 18/04/2016 | Southampton FC U21 | - | Norwich City U21 | 3:2 | ||||
| 22. Round | 25/04/2016 | Southampton FC U21 | - | Manchester United U21 | 2:1 |
England