| 3. Round | 04/07/2021 | Orlando Pride [Women] | - | NC Courage [Women] | 0:2 | ||||
| 3. Round | 10/07/2021 | Orlando Pride [Women] | - | Racing Louisville [Women] | 1:1 | ||||
| 3. Round | 19/07/2021 | Portland Thorns [Women] | - | Orlando Pride [Women] | 2:1 | ||||
| 3. Round | 25/07/2021 | Orlando Pride [Women] | - | OL Reign [Women] | 0:2 |  |
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| 4. Round | 31/07/2021 | NC Courage [Women] | - | Orlando Pride [Women] | 1:1 | ||||
| 4. Round | 08/08/2021 | Chicago Red Stars [Women] | - | Orlando Pride [Women] | 0:2 | |
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| 4. Round | 15/08/2021 | Orlando Pride [Women] | - | Portland Thorns [Women] | 1:1 | ||||
| 4. Round | 22/08/2021 | Washington Spirit [Women] | - | Orlando Pride [Women] | 2:1 | |
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| 5. Round | 05/09/2021 | Orlando Pride [Women] | - | Houston Dash [Women] | 1:1 | ||||
| 5. Round | 12/09/2021 | Orlando Pride [Women] | - | Racing Louisville [Women] | 3:1 | ||||
| 5. Round | 27/09/2021 | OL Reign [Women] | - | Orlando Pride [Women] | 3:0 | |
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| 6. Round | 10/10/2021 | Orlando Pride [Women] | - | NJ/NY Gotham FC [Women] | 2:3 | ||||
| 6. Round | 14/10/2021 | Chicago Red Stars [Women] | - | Orlando Pride [Women] | 1:0 | ||||
| 6. Round | 17/10/2021 | Racing Louisville [Women] | - | Orlando Pride [Women] | 3:1 |
England