| 5. Round | 22/08/2021 | ŠKF Sereď | - | Slovan Bratislava | 0:1 | ||||
| 6. Round | 29/08/2021 | Slovan Bratislava | - | Zlaté Moravce | 4:1 | ||||
| 7. Round | 12/09/2021 | FC DAC 1904 | - | Slovan Bratislava | 1:1 | ||||
| 8. Round | 19/09/2021 | Slovan Bratislava | - | MŠK Žilina | 2:2 | ||||
| 3. Round | 22/09/2021 | MFK Ružomberok | - | Slovan Bratislava | 1:0 | ||||
| 9. Round | 25/09/2021 | FK Senica | - | Slovan Bratislava | 0:3 |  |
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| 12. Round | 24/10/2021 | Slovan Bratislava | - | Tatran Liptovský Mikuláš | 4:0 | ||||
| 13. Round | 31/10/2021 | AS Trenčín | - | Slovan Bratislava | 2:3 | ||||
| 14. Round | 07/11/2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Round | 21/11/2021 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 | ||||
| 16. Round | 29/11/2021 | Slovan Bratislava | - | ŠKF Sereď | 2:0 |  |
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| 17. Round | 03/12/2021 | Zlaté Moravce | - | Slovan Bratislava | 1:2 | ||||
| 18. Round | 12/12/2021 | Slovan Bratislava | - | FC DAC 1904 | 0:0 | ||||
| 19. Round | 19/12/2021 | MŠK Žilina | - | Slovan Bratislava | 1:1 | ||||
| 20. Round | 12/02/2022 | Slovan Bratislava | - | FK Senica | 5:0 | ||||
| 21. Round | 19/02/2022 | FK Pohronie | - | Slovan Bratislava | 3:4 | |
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| 22. Round | 26/02/2022 | Slovan Bratislava | - | Spartak Trnava | 0:0 |
England