| 1. Round | 13/09/2020 | Sparta Rotterdam | - | AFC Ajax | 0:1 |  |
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| 2. Round | 20/09/2020 | AFC Ajax | - | RKC Waalwijk | 3:0 | ||||
| 3. Round | 26/09/2020 | AFC Ajax | - | Vitesse | 2:1 | ||||
| 4. Round | 04/10/2020 | FC Groningen | - | AFC Ajax | 1:0 | ||||
| 5. Round | 18/10/2020 | AFC Ajax | - | sc Heerenveen | 5:1 | ||||
| 6. Round | 24/10/2020 | VVV-Venlo | - | AFC Ajax | 0:13 | ||||
| 7. Round | 31/10/2020 | AFC Ajax | - | Fortuna Sittard | 5:2 | ||||
| 8. Round | 08/11/2020 | FC Utrecht | - | AFC Ajax | 0:3 | ||||
| 9. Round | 22/11/2020 | AFC Ajax | - | Heracles Almelo | 5:0 | ||||
| 10. Round | 28/11/2020 | FC Emmen | - | AFC Ajax | 0:5 | ||||
| 11. Round | 05/12/2020 | AFC Ajax | - | FC Twente | 1:2 | ||||
| 12. Round | 12/12/2020 | AFC Ajax | - | PEC Zwolle | 4:0 | ||||
| 13. Round | 20/12/2020 | ADO Den Haag | - | AFC Ajax | 2:4 | ||||
| 14. Round | 23/12/2020 | Willem II | - | AFC Ajax | 1:1 | ||||
| 15. Round | 10/01/2021 | AFC Ajax | - | PSV Eindhoven | 2:2 | ||||
| 16. Round | 14/01/2021 | FC Twente | - | AFC Ajax | 1:3 | ||||
| 17. Round | 17/01/2021 | AFC Ajax | - | Feyenoord | 1:0 | ||||
| 18. Round | 24/01/2021 | Fortuna Sittard | - | AFC Ajax | 1:2 | ||||
| 19. Round | 28/01/2021 | AFC Ajax | - | Willem II | 3:1 | ||||
| 20. Round | 31/01/2021 | AZ Alkmaar | - | AFC Ajax | 0:3 |
Cameroon
