| 23. Round | 06/02/2022 | Stade de Reims | - | Girondins Bordeaux | 5:0 | ||||
| 24. Round | 13/02/2022 | RC Lens | - | Girondins Bordeaux | 3:2 | ||||
| 25. Round | 20/02/2022 | Girondins Bordeaux | - | AS Monaco | 1:1 | ||||
| 26. Round | 27/02/2022 | Clermont Foot 63 | - | Girondins Bordeaux | 1:1 |  |
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| 27. Round | 06/03/2022 | Girondins Bordeaux | - | ESTAC Troyes | 0:2 | |
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| 28. Round | 13/03/2022 | Paris Saint-Germain | - | Girondins Bordeaux | 3:0 | ||||
| 29. Round | 20/03/2022 | Girondins Bordeaux | - | Montpellier HSC | 0:2 | |
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| 31. Round | 10/04/2022 | Girondins Bordeaux | - | FC Metz | 3:1 | ||||
| 32. Round | 17/04/2022 | Olympique Lyonnais | - | Girondins Bordeaux | 6:1 | ||||
| 33. Round | 20/04/2022 | Girondins Bordeaux | - | AS Saint-Étienne | 2:2 | |
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| 34. Round | 24/04/2022 | FC Nantes | - | Girondins Bordeaux | 5:3 | ||||
| 35. Round | 01/05/2022 | Girondins Bordeaux | - | OGC Nice | 0:1 | ||||
| 36. Round | 08/05/2022 | Angers SCO | - | Girondins Bordeaux | 4:1 | |
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| 37. Round | 14/05/2022 | Girondins Bordeaux | - | FC Lorient | 0:0 | |
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| 38. Round | 21/05/2022 | Stade Brestois 29 | - | Girondins Bordeaux | 2:4 |
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