| 1. Round | 10/08/2015 | Southampton FC U21 | - | Manchester City U21 | 2:2 | ||||
| 2. Round | 14/08/2015 | Manchester City U21 | - | Tottenham Hotspur U21 | 3:3 | ||||
| 5. Round | 20/09/2015 | Sunderland AFC U21 | - | Manchester City U21 | 3:0 | ||||
| 6. Round | 25/09/2015 | Manchester City U21 | - | Middlesbrough FC U21 | 5:1 |  |
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| 11. Round | 04/10/2015 | Manchester City U21 | - | Leicester City U21 | 1:3 | ||||
| 8. Round | 26/10/2015 | Chelsea FC U21 | - | Manchester City U21 | 0:2 | ||||
| 4. Round | 08/11/2015 | Manchester City U21 | - | Norwich City U21 | 1:0 | |
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| 13. Round | 14/12/2015 | Manchester City U21 | - | Southampton FC U21 | 3:1 | ||||
| 14. Round | 11/01/2016 | Manchester City U21 | - | Everton FC U21 | 0:1 | ||||
| 12. Round | 18/01/2016 | Tottenham Hotspur U21 | - | Manchester City U21 | 2:2 | ||||
| 7. Round | 22/01/2016 | Manchester City U21 | - | Reading FC U21 | 3:1 |  |
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| 17. Round | 07/02/2016 | Liverpool FC U21 | - | Manchester City U21 | 0:3 | |
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| 3. Round | 11/02/2016 | Manchester United U21 | - | Manchester City U21 | 1:0 | ||||
| 16. Round | 15/02/2016 | Leicester City U21 | - | Manchester City U21 | 1:0 | ||||
| 18. Round | 20/02/2016 | Manchester City U21 | - | Manchester United U21 | 1:0 | |
England