| 18. Round | 26/12/2022 | Sporting Charleroi | - | RSC Anderlecht | 0:1 | ||||
| 19. Round | 08/01/2023 | RSC Anderlecht | - | Union Saint-Gilloise | 1:3 | ||||
| 20. Round | 15/01/2023 | Club Brugge KV | - | RSC Anderlecht | 1:1 | ||||
| 21. Round | 18/01/2023 | RSC Anderlecht | - | SV Zulte Waregem | 2:3 | ||||
| 22. Round | 22/01/2023 | RFC Seraing | - | RSC Anderlecht | 0:1 | ||||
| 23. Round | 29/01/2023 | RSC Anderlecht | - | Royal Antwerp FC | 0:0 | ||||
| 24. Round | 03/02/2023 | KV Oostende | - | RSC Anderlecht | 0:2 | ||||
| 25. Round | 12/02/2023 | RSC Anderlecht | - | Sint-Truidense VV | 3:1 | ||||
| 26. Round | 19/02/2023 | KV Kortrijk | - | RSC Anderlecht | 2:2 | ||||
| 27. Round | 26/02/2023 | RSC Anderlecht | - | Standard Liège | 2:2 | ||||
| 28. Round | 05/03/2023 | KAA Gent | - | RSC Anderlecht | 1:0 | ||||
| 29. Round | 12/03/2023 | RSC Anderlecht | - | Cercle Brugge | 2:0 | ||||
| 30. Round | 19/03/2023 | Oud-Heverlee Leuven | - | RSC Anderlecht | 0:2 | ||||
| 31. Round | 02/04/2023 | KAS Eupen | - | RSC Anderlecht | 0:1 | ||||
| 32. Round | 09/04/2023 | RSC Anderlecht | - | KVC Westerlo | 0:0 | ||||
| 33. Round | 16/04/2023 | KRC Genk | - | RSC Anderlecht | 5:2 | ||||
| 34. Round | 23/04/2023 | RSC Anderlecht | - | KV Mechelen | 2:3 |
Netherlands