| 4. Round | 20/09/2024 | Southampton FC U21 | - | Norwich City U21 | 2:3 |  |
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| 5. Round | 27/09/2024 | West Bromwich Albion U21 | - | Southampton FC U21 | 1:1 | ||||
| 6. Round | 04/10/2024 | Nottingham Forest U21 | - | Southampton FC U21 | 0:2 |  |
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| 7. Round | 25/10/2024 | Southampton FC U21 | - | Crystal Palace U21 | 0:2 | ||||
| 8. Round | 01/11/2024 | Southampton FC U21 | - | Brighton & Hove Albion U21 | 2:4 | ||||
| 9. Round | 29/11/2024 | Stoke City U21 | - | Southampton FC U21 | 0:3 | ||||
| 10. Round | 14/12/2024 | Manchester United U21 | - | Southampton FC U21 | 5:1 | |
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| 11. Round | 10/01/2025 | Southampton FC U21 | - | Fulham FC U21 | 5:0 | ||||
| 13. Round | 24/01/2025 | Chelsea FC U21 | - | Southampton FC U21 | 0:2 | ||||
| 14. Round | 07/02/2025 | Southampton FC U21 | - | Liverpool FC U21 | 1:1 | ||||
| 15. Round | 14/02/2025 | Everton FC U21 | - | Southampton FC U21 | 1:2 | |
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| 16. Round | 21/02/2025 | Southampton FC U21 | - | Sunderland AFC U21 | 3:3 | ||||
| 18. Round | 16/03/2025 | Middlesbrough FC U21 | - | Southampton FC U21 | 1:0 |
England