| 1. Round | 17/08/2024 | Newcastle United | - | Southampton FC | 1:0 |  |
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| 2. Round | 24/08/2024 | Southampton FC | - | Nottingham Forest | 0:1 | ||||
| 3. Round | 31/08/2024 | Brentford FC | - | Southampton FC | 3:1 | ||||
| 4. Round | 14/09/2024 | Southampton FC | - | Manchester United | 0:3 | ||||
| 5. Round | 21/09/2024 | Southampton FC | - | Ipswich Town | 1:1 | ||||
| 6. Round | 30/09/2024 | AFC Bournemouth | - | Southampton FC | 3:1 | ||||
| 11. Round | 09/11/2024 | Wolverhampton Wanderers | - | Southampton FC | 2:0 | ||||
| 13. Round | 29/11/2024 | Brighton & Hove Albion | - | Southampton FC | 1:1 | ||||
| 14. Round | 04/12/2024 | Southampton FC | - | Chelsea FC | 1:5 | ||||
| 15. Round | 07/12/2024 | Aston Villa | - | Southampton FC | 1:0 |
England
