| 16. Round | 10/01/2022 | Aston Villa U23 | - | Middlesbrough FC U23 | 1:2 | ||||
| 17. Round | 17/01/2022 | West Bromwich Albion U23 | - | Aston Villa U23 | 2:1 | ||||
| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 20. Round | 21/02/2022 | Aston Villa U23 | - | Norwich City U23 | 2:0 | ||||
| 26. Round | 02/05/2022 | Aston Villa U23 | - | Newcastle United U23 | 1:2 |
England