| 4. Round | 12/09/2021 | Reading FC U23 | - | Nottingham Forest U23 | 0:2 | ||||
| 5. Round | 20/09/2021 | Reading FC U23 | - | Norwich City U23 | 3:3 | ||||
| 6. Round | 27/09/2021 | Burnley FC U23 | - | Reading FC U23 | 3:1 | ||||
| 7. Round | 04/10/2021 | Reading FC U23 | - | Birmingham City U23 | 1:1 | ||||
| 8. Round | 15/10/2021 | Fulham FC U23 | - | Reading FC U23 | 3:0 | ||||
| 10. Round | 01/11/2021 | Reading FC U23 | - | Sunderland AFC U23 | 0:3 | ||||
| 11. Round | 08/11/2021 | Reading FC U23 | - | Aston Villa U23 | 2:2 | ||||
| 12. Round | 22/11/2021 | West Bromwich Albion U23 | - | Reading FC U23 | 1:1 |  |
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| 13. Round | 29/11/2021 | Reading FC U23 | - | Middlesbrough FC U23 | 2:1 | |
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| 14. Round | 03/12/2021 | Norwich City U23 | - | Reading FC U23 | 5:2 | |
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| 18. Round | 24/01/2022 | Aston Villa U23 | - | Reading FC U23 | 4:1 | ||||
| 20. Round | 21/02/2022 | Nottingham Forest U23 | - | Reading FC U23 | 7:0 | |
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| 23. Round | 20/03/2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 |
Wales
England