| 2. Round | 14/08/2021 | Oxford United | - | Charlton Athletic | 2:1 | ||||
| 3. Round | 17/08/2021 | Milton Keynes Dons | - | Charlton Athletic | 2:1 | ||||
| 4. Round | 21/08/2021 | Charlton Athletic | - | Wigan Athletic | 0:2 |  |
|||
| 5. Round | 28/08/2021 | Charlton Athletic | - | Crewe Alexandra | 2:0 | ||||
| 7. Round | 11/09/2021 | Charlton Athletic | - | Cheltenham Town | 1:2 | ||||
| 6. Round | 21/09/2021 | Gillingham FC | - | Charlton Athletic | 1:1 | ||||
| 9. Round | 25/09/2021 | Charlton Athletic | - | Portsmouth FC | 2:2 | ||||
| 10. Round | 28/09/2021 | Charlton Athletic | - | Bolton Wanderers | 1:4 | ||||
| 13. Round | 16/10/2021 | Lincoln City | - | Charlton Athletic | 2:1 |
England
