| 2. Round | 11/08/2018 | Carlisle United | - | Northampton Town | 2:2 | ||||
| 5. Round | 25/08/2018 | Colchester United | - | Northampton Town | 1:2 |  |
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| 6. Round | 01/09/2018 | Northampton Town | - | Tranmere Rovers | 1:1 | ||||
| 8. Round | 15/09/2018 | Port Vale FC | - | Northampton Town | 2:0 | ||||
| 10. Round | 29/09/2018 | Mansfield Town | - | Northampton Town | 4:0 | ||||
| 11. Round | 02/10/2018 | Northampton Town | - | Bury FC | 0:0 | ||||
| 12. Round | 06/10/2018 | Swindon Town | - | Northampton Town | 1:1 |  |
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| 13. Round | 13/10/2018 | Northampton Town | - | Forest Green Rovers | 2:1 | ||||
| 14. Round | 20/10/2018 | Milton Keynes Dons | - | Northampton Town | 1:0 | ||||
| 15. Round | 23/10/2018 | Macclesfield Town | - | Northampton Town | 0:5 | ||||
| 17. Round | 03/11/2018 | Northampton Town | - | Crewe Alexandra | 2:0 | ||||
| 18. Round | 17/11/2018 | Exeter City | - | Northampton Town | 2:2 | |
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| 20. Round | 27/11/2018 | Newport County | - | Northampton Town | 3:1 | ||||
| 23. Round | 22/12/2018 | Yeovil Town | - | Northampton Town | 1:1 | ||||
| 25. Round | 29/12/2018 | Northampton Town | - | Milton Keynes Dons | 2:2 |
England