| 2. Round | 14/08/2021 | Plymouth Argyle | - | Gillingham FC | 1:0 | ||||
| 4. Round | 21/08/2021 | Shrewsbury Town | - | Plymouth Argyle | 0:3 | ||||
| 5. Round | 28/08/2021 | Plymouth Argyle | - | Fleetwood Town | 1:1 | ||||
| 7. Round | 11/09/2021 | Plymouth Argyle | - | Sheffield Wednesday | 3:0 | ||||
| 8. Round | 18/09/2021 | AFC Wimbledon | - | Plymouth Argyle | 0:1 | ||||
| 6. Round | 21/09/2021 | Portsmouth FC | - | Plymouth Argyle | 2:2 | ||||
| 9. Round | 25/09/2021 | Plymouth Argyle | - | Doncaster Rovers | 2:1 |  |
|||
| 10. Round | 28/09/2021 | Plymouth Argyle | - | Crewe Alexandra | 1:1 | |
|||
| 11. Round | 02/10/2021 | Lincoln City | - | Plymouth Argyle | 2:2 |  |
|||
| 13. Round | 16/10/2021 | Oxford United | - | Plymouth Argyle | 1:3 | ||||
| 14. Round | 19/10/2021 | Plymouth Argyle | - | Bolton Wanderers | 3:0 | |
|
||
| 15. Round | 23/10/2021 | Morecambe FC | - | Plymouth Argyle | 1:1 | |
|||
| 16. Round | 30/10/2021 | Plymouth Argyle | - | Ipswich Town | 2:1 | ||||
| 19. Round | 23/11/2021 | Plymouth Argyle | - | Wycombe Wanderers | 0:3 |
Zimbabwe
England 
