| 1. Round | 06/08/2011 | Walsall FC | - | Leyton Orient | 1:0 | ||||
| 2. Round | 13/08/2011 | Leyton Orient | - | Tranmere Rovers | 0:1 | ||||
| 3. Round | 16/08/2011 | Leyton Orient | - | Wycombe Wanderers | 1:3 | ||||
| 4. Round | 20/08/2011 | Brentford FC | - | Leyton Orient | 5:0 | ||||
| 5. Round | 27/08/2011 | Leyton Orient | - | Carlisle United | 1:2 | ||||
| 6. Round | 03/09/2011 | Chesterfield FC | - | Leyton Orient | 0:0 | ||||
| 7. Round | 10/09/2011 | Colchester United | - | Leyton Orient | 1:1 |  |
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| 8. Round | 13/09/2011 | Leyton Orient | - | AFC Bournemouth | 1:3 | ||||
| 9. Round | 17/09/2011 | Leyton Orient | - | Oldham Athletic | 1:3 | ||||
| 12. Round | 08/10/2011 | Scunthorpe United | - | Leyton Orient | 2:3 | |
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| 13. Round | 15/10/2011 | Leyton Orient | - | Bury FC | 1:0 | ||||
| 14. Round | 22/10/2011 | Leyton Orient | - | Sheffield United | 1:1 |  |
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| 18. Round | 19/11/2011 | Leyton Orient | - | Stevenage FC | 0:0 |
England
