| 1. Round | 15/08/2021 | Manchester United U23 | - | Leicester City U23 | 2:2 |  |
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| 2. Round | 20/08/2021 | Chelsea FC U23 | - | Manchester United U23 | 1:1 | ||||
| 3. Round | 28/08/2021 | Manchester United U23 | - | Manchester City U23 | 2:4 | ||||
| 4. Round | 11/09/2021 | Arsenal FC U23 | - | Manchester United U23 | 3:1 | ||||
| 5. Round | 18/09/2021 | Manchester United U23 | - | Brighton & Hove Albion U23 | 2:1 | ||||
| 7. Round | 02/10/2021 | Manchester United U23 | - | Liverpool FC U23 | 3:0 | ||||
| 8. Round | 16/10/2021 | Manchester United U23 | - | Blackburn Rovers U23 | 3:0 | ||||
| 10. Round | 30/10/2021 | Tottenham Hotspur U23 | - | Manchester United U23 | 1:0 | ||||
| 11. Round | 06/11/2021 | Manchester United U23 | - | Leeds United U23 | 3:2 | |
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| 12. Round | 19/11/2021 | Derby County U23 | - | Manchester United U23 | 1:1 | |
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| 13. Round | 27/11/2021 | Manchester United U23 | - | Crystal Palace U23 | 1:2 | |
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| 14. Round | 05/12/2021 | Blackburn Rovers U23 | - | Manchester United U23 | 0:4 | ||||
| 16. Round | 10/01/2022 | Manchester United U23 | - | Tottenham Hotspur U23 | 1:1 |
England