| 5. Round | 20/09/2021 | Wolverhampton Wanderers U23 | - | Fulham FC U23 | 2:1 | ||||
| 11. Round | 08/11/2021 | Burnley FC U23 | - | Fulham FC U23 | 1:2 | ||||
| 12. Round | 19/11/2021 | Fulham FC U23 | - | Stoke City U23 | 3:0 | ||||
| 14. Round | 03/12/2021 | Fulham FC U23 | - | Wolverhampton Wanderers U23 | 4:2 |  |
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| 15. Round | 20/12/2021 | West Bromwich Albion U23 | - | Fulham FC U23 | 2:4 | ||||
| 16. Round | 10/01/2022 | Nottingham Forest U23 | - | Fulham FC U23 | 1:2 | ||||
| 17. Round | 17/01/2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
| 18. Round | 24/01/2022 | Stoke City U23 | - | Fulham FC U23 | 0:1 | ||||
| 13. Round | 30/01/2022 | Birmingham City U23 | - | Fulham FC U23 | 1:3 | ||||
| 20. Round | 21/02/2022 | Newcastle United U23 | - | Fulham FC U23 | 1:6 | ||||
| 21. Round | 25/02/2022 | Fulham FC U23 | - | Aston Villa U23 | 2:1 | ||||
| 22. Round | 11/03/2022 | Fulham FC U23 | - | Norwich City U23 | 1:2 | ||||
| 23. Round | 18/03/2022 | Middlesbrough FC U23 | - | Fulham FC U23 | 0:0 | ||||
| 24. Round | 01/04/2022 | Fulham FC U23 | - | Birmingham City U23 | 3:0 | ||||
| 25. Round | 25/04/2022 | Reading FC U23 | - | Fulham FC U23 | 3:1 | ||||
| 26. Round | 29/04/2022 | Fulham FC U23 | - | Burnley FC U23 | 5:3 |
England