| 1. Round | 06/08/2022 | Arsenal FC U21 | - | Manchester United U21 | 3:1 | ||||
| 2. Round | 12/08/2022 | Manchester United U21 | - | Crystal Palace U21 | 1:5 |  |
|||
| 3. Round | 19/08/2022 | Everton FC U21 | - | Manchester United U21 | 2:2 | ||||
| 4. Round | 26/08/2022 | Manchester United U21 | - | Fulham FC U21 | 2:2 | ||||
| 5. Round | 03/09/2022 | Liverpool FC U21 | - | Manchester United U21 | 2:2 | ||||
| 7. Round | 16/09/2022 | Manchester United U21 | - | West Ham United U21 | 1:1 | ||||
| 8. Round | 01/10/2022 | Blackburn Rovers U21 | - | Manchester United U21 | 6:1 | ||||
| 9. Round | 08/10/2022 | Manchester United U21 | - | Brighton & Hove Albion U21 | 3:3 |  |
|||
| 10. Round | 15/10/2022 | Chelsea FC U21 | - | Manchester United U21 | 3:3 | ||||
| 11. Round | 22/10/2022 | Manchester United U21 | - | Wolverhampton Wanderers U21 | 3:2 | ||||
| 12. Round | 29/10/2022 | Tottenham Hotspur U21 | - | Manchester United U21 | 1:1 | ||||
| 13. Round | 05/11/2022 | Manchester United U21 | - | Manchester City U21 | 1:6 | ||||
| 15. Round | 14/01/2023 | Manchester United U21 | - | Liverpool FC U21 | 2:1 | |
England