| 11. Round | 04/12/2021 | Crystal Palace [U18] | - | Tottenham Hotspur [U18] | 3:0 | ||||
| 12. Round | 11/12/2021 | Tottenham Hotspur [U18] | - | Leicester City [U18] | 0:3 | ||||
| 14. Round | 15/01/2022 | Southampton FC [U18] | - | Tottenham Hotspur [U18] | 1:2 |  |
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| 17. Round | 19/02/2022 | Leicester City [U18] | - | Tottenham Hotspur [U18] | 4:1 | ||||
| 19. Round | 05/03/2022 | Tottenham Hotspur [U18] | - | Fulham FC [U18] | 0:1 | ||||
| 22. Round | 02/04/2022 | Reading FC [U18] | - | Tottenham Hotspur [U18] | 1:2 | ||||
| 23. Round | 09/04/2022 | West Ham United [U18] | - | Tottenham Hotspur [U18] | 3:5 | ||||
| 7. Round | 15/04/2022 | Tottenham Hotspur [U18] | - | Norwich City [U18] | 2:1 | ||||
| 20. Round | 19/04/2022 | Chelsea FC [U18] | - | Tottenham Hotspur [U18] | 3:2 | ||||
| 24. Round | 23/04/2022 | Tottenham Hotspur [U18] | - | West Bromwich Albion [U18] | 2:1 |
England