| 1. Round | 08/08/2022 | Leicester City U21 | - | Tottenham Hotspur U21 | 2:2 | ||||
| 2. Round | 12/08/2022 | Tottenham Hotspur U21 | - | Everton FC U21 | 0:2 | ||||
| 3. Round | 21/08/2022 | Manchester City U21 | - | Tottenham Hotspur U21 | 0:0 | ||||
| 4. Round | 26/08/2022 | Tottenham Hotspur U21 | - | Liverpool FC U21 | 3:3 | ||||
| 13. Round | 07/11/2022 | Chelsea FC U21 | - | Tottenham Hotspur U21 | 3:0 | ||||
| 17. Round | 27/01/2023 | Arsenal FC U21 | - | Tottenham Hotspur U21 | 1:2 | ||||
| 20. Round | 27/02/2023 | Tottenham Hotspur U21 | - | Crystal Palace U21 | 1:1 | ||||
| 21. Round | 03/03/2023 | Fulham FC U21 | - | Tottenham Hotspur U21 | 4:3 |  |
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| 22. Round | 17/03/2023 | Tottenham Hotspur U21 | - | Leicester City U21 | 3:1 | ||||
| 23. Round | 03/04/2023 | Tottenham Hotspur U21 | - | Manchester City U21 | 1:2 | ||||
| 16. Round | 07/04/2023 | Tottenham Hotspur U21 | - | Wolverhampton Wanderers U21 | 1:1 |  |
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| 24. Round | 15/04/2023 | Blackburn Rovers U21 | - | Tottenham Hotspur U21 | 3:2 | ||||
| 25. Round | 24/04/2023 | Tottenham Hotspur U21 | - | Chelsea FC U21 | 3:2 |
England