| 1. Round | 06/08/2022 | Arsenal FC U21 | - | Manchester United U21 | 3:1 |  |
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| 2. Round | 12/08/2022 | Manchester United U21 | - | Crystal Palace U21 | 1:5 | ||||
| 4. Round | 26/08/2022 | Manchester United U21 | - | Fulham FC U21 | 2:2 | ||||
| 18. Round | 11/02/2023 | Manchester United U21 | - | Everton FC U21 | 4:1 |  |
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| 19. Round | 20/02/2023 | Crystal Palace U21 | - | Manchester United U21 | 0:0 | |
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| 20. Round | 24/02/2023 | Wolverhampton Wanderers U21 | - | Manchester United U21 | 2:2 | ||||
| 22. Round | 19/03/2023 | Manchester City U21 | - | Manchester United U21 | 6:0 | ||||
| 23. Round | 31/03/2023 | Manchester United U21 | - | Arsenal FC U21 | 1:1 | ||||
| 24. Round | 17/04/2023 | Leicester City U21 | - | Manchester United U21 | 3:2 | ||||
| 26. Round | 28/04/2023 | Manchester United U21 | - | Tottenham Hotspur U21 | 2:2 | ||||
| 6. Round | 05/05/2023 | Manchester United U21 | - | Leicester City U21 | 2:2 |
England