| 26. Round | 16/01/2010 | Plymouth Argyle | - | Crystal Palace | 0:1 | ||||
| 27. Round | 26/01/2010 | Plymouth Argyle | - | Derby County | 1:0 | ||||
| 31. Round | 13/02/2010 | Barnsley FC | - | Plymouth Argyle | 1:3 | ||||
| 32. Round | 16/02/2010 | Plymouth Argyle | - | Swansea City | 1:1 | ||||
| 33. Round | 20/02/2010 | Plymouth Argyle | - | Leicester City | 1:1 | ||||
| 34. Round | 27/02/2010 | Sheffield United | - | Plymouth Argyle | 4:3 | ||||
| 35. Round | 06/03/2010 | Plymouth Argyle | - | Preston North End | 1:1 | ||||
| 25. Round | 09/03/2010 | Queens Park Rangers | - | Plymouth Argyle | 2:0 |  |
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| 36. Round | 13/03/2010 | Coventry City | - | Plymouth Argyle | 1:1 | ||||
| 37. Round | 16/03/2010 | Plymouth Argyle | - | Bristol City | 3:2 | ||||
| 38. Round | 20/03/2010 | Scunthorpe United | - | Plymouth Argyle | 2:1 | ||||
| 39. Round | 23/03/2010 | Ipswich Town | - | Plymouth Argyle | 0:2 | ||||
| 45. Round | 24/04/2010 | Nottingham Forest | - | Plymouth Argyle | 3:0 | ||||
| 46. Round | 02/05/2010 | Plymouth Argyle | - | Peterborough United | 1:2 |
England
