| 4. Round | 21/08/2021 | Scunthorpe United | - | Sutton United | 1:1 | ||||
| 9. Round | 25/09/2021 | Sutton United | - | Carlisle United | 4:0 | ||||
| 11. Round | 09/10/2021 | Sutton United | - | Port Vale FC | 4:3 |  |
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| 12. Round | 16/10/2021 | Crawley Town | - | Sutton United | 0:1 | ||||
| 14. Round | 23/10/2021 | Rochdale AFC | - | Sutton United | 3:2 | ||||
| 6. Round | 26/10/2021 | Colchester United | - | Sutton United | 1:3 | ||||
| 15. Round | 30/10/2021 | Sutton United | - | Walsall FC | 0:1 | ||||
| 16. Round | 13/11/2021 | Tranmere Rovers | - | Sutton United | 0:1 | ||||
| 23. Round | 15/02/2022 | Bristol Rovers | - | Sutton United | 2:0 |  |
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| 34. Round | 26/02/2022 | Sutton United | - | Scunthorpe United | 4:1 | ||||
| 36. Round | 12/03/2022 | Walsall FC | - | Sutton United | 1:0 | ||||
| 37. Round | 15/03/2022 | Swindon Town | - | Sutton United | 2:1 | |
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| 38. Round | 19/03/2022 | Sutton United | - | Tranmere Rovers | 1:1 | ||||
| 26. Round | 22/03/2022 | Oldham Athletic | - | Sutton United | 1:3 | ||||
| 41. Round | 09/04/2022 | Sutton United | - | Leyton Orient | 1:0 |
England