| 1. Round | 06/08/2022 | PSV Eindhoven | - | FC Emmen | 4:1 |  |
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| 2. Round | 13/08/2022 | Go Ahead Eagles | - | PSV Eindhoven | 2:5 | ||||
| 4. Round | 28/08/2022 | SBV Excelsior | - | PSV Eindhoven | 1:6 | |
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| 3. Round | 31/08/2022 | PSV Eindhoven | - | FC Volendam | 7:1 | |
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| 5. Round | 03/09/2022 | FC Twente | - | PSV Eindhoven | 2:1 | ||||
| 6. Round | 11/09/2022 | PSV Eindhoven | - | RKC Waalwijk | 1:0 | |
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| 7. Round | 18/09/2022 | PSV Eindhoven | - | Feyenoord | 4:3 | |
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| 8. Round | 01/10/2022 | SC Cambuur | - | PSV Eindhoven | 3:0 | ||||
| 9. Round | 09/10/2022 | sc Heerenveen | - | PSV Eindhoven | 0:1 | |
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| 10. Round | 16/10/2022 | PSV Eindhoven | - | FC Utrecht | 6:1 | ||||
| 11. Round | 23/10/2022 | FC Groningen | - | PSV Eindhoven | 4:2 | ||||
| 12. Round | 30/10/2022 | PSV Eindhoven | - | NEC Nijmegen | 3:0 | ||||
| 13. Round | 06/11/2022 | AFC Ajax | - | PSV Eindhoven | 1:2 | ||||
| 14. Round | 12/11/2022 | PSV Eindhoven | - | AZ Alkmaar | 0:1 |
Netherlands
Togo 
