| 1. Round | 16/08/2021 | Blackburn Rovers U23 | - | Everton FC U23 | 2:2 | ||||
| 2. Round | 20/08/2021 | Manchester City U23 | - | Blackburn Rovers U23 | 4:2 | ||||
| 3. Round | 27/08/2021 | Blackburn Rovers U23 | - | Leicester City U23 | 1:1 | ||||
| 5. Round | 17/09/2021 | Blackburn Rovers U23 | - | Tottenham Hotspur U23 | 3:3 |  |
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| 6. Round | 24/09/2021 | Leeds United U23 | - | Blackburn Rovers U23 | 4:4 | ||||
| 7. Round | 03/10/2021 | Chelsea FC U23 | - | Blackburn Rovers U23 | 0:1 | ||||
| 8. Round | 16/10/2021 | Manchester United U23 | - | Blackburn Rovers U23 | 3:0 | ||||
| 9. Round | 25/10/2021 | Blackburn Rovers U23 | - | Liverpool FC U23 | 2:2 | ||||
| 11. Round | 05/11/2021 | Derby County U23 | - | Blackburn Rovers U23 | 6:0 | ||||
| 12. Round | 22/11/2021 | Blackburn Rovers U23 | - | Arsenal FC U23 | 2:3 | |
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| 13. Round | 26/11/2021 | West Ham United U23 | - | Blackburn Rovers U23 | 1:0 | ||||
| 14. Round | 05/12/2021 | Blackburn Rovers U23 | - | Manchester United U23 | 0:4 | ||||
| 16. Round | 09/01/2022 | Blackburn Rovers U23 | - | Manchester City U23 | 3:5 | |
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| 17. Round | 17/01/2022 | Tottenham Hotspur U23 | - | Blackburn Rovers U23 | 1:1 | |
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| 18. Round | 24/01/2022 | Blackburn Rovers U23 | - | Leeds United U23 | 4:0 |
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