| 1. Round | 10/08/2015 | Middlesbrough FC U21 | - | Reading FC U21 | 1:1 | ||||
| 2. Round | 17/08/2015 | Reading FC U21 | - | Sunderland AFC U21 | 2:1 | ||||
| 3. Round | 24/08/2015 | Reading FC U21 | - | Liverpool FC U21 | 2:1 | ||||
| 5. Round | 21/09/2015 | Reading FC U21 | - | Southampton FC U21 | 2:5 | ||||
| 6. Round | 25/09/2015 | Chelsea FC U21 | - | Reading FC U21 | 3:3 | ||||
| 8. Round | 26/10/2015 | Reading FC U21 | - | Norwich City U21 | 2:0 | ||||
| 10. Round | 23/11/2015 | Leicester City U21 | - | Reading FC U21 | 2:1 | ||||
| 12. Round | 06/12/2015 | Sunderland AFC U21 | - | Reading FC U21 | 2:1 | ||||
| 7. Round | 22/01/2016 | Manchester City U21 | - | Reading FC U21 | 3:1 | ||||
| 16. Round | 31/01/2016 | Liverpool FC U21 | - | Reading FC U21 | 2:0 | ||||
| 18. Round | 22/02/2016 | Southampton FC U21 | - | Reading FC U21 | 1:1 |  |
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| 21. Round | 03/03/2016 | Reading FC U21 | - | Tottenham Hotspur U21 | 1:1 | ||||
| 19. Round | 07/03/2016 | Reading FC U21 | - | Chelsea FC U21 | 1:3 | ||||
| 20. Round | 14/03/2016 | Everton FC U21 | - | Reading FC U21 | 0:2 | ||||
| 15. Round | 21/03/2016 | Norwich City U21 | - | Reading FC U21 | 4:4 | ||||
| 22. Round | 11/04/2016 | Reading FC U21 | - | Manchester City U21 | 0:3 |
Ireland