| 4. Round | 21/08/2021 | Gillingham FC | - | Morecambe FC | 2:1 | ||||
| 5. Round | 28/08/2021 | Morecambe FC | - | Sheffield Wednesday | 1:0 | ||||
| 19. Round | 23/11/2021 | Morecambe FC | - | Charlton Athletic | 2:2 | ||||
| 20. Round | 27/11/2021 | Morecambe FC | - | Milton Keynes Dons | 0:4 | ||||
| 21. Round | 07/12/2021 | Sunderland AFC | - | Morecambe FC | 5:0 | ||||
| 29. Round | 22/01/2022 | Morecambe FC | - | Wycombe Wanderers | 3:2 | ||||
| 35. Round | 22/02/2022 | Rotherham United | - | Morecambe FC | 2:0 |
England