| 5. Round | 19/09/2021 | Brighton & Hove Albion | - | Leicester City | 2:1 | ||||
| 6. Round | 27/09/2021 | Crystal Palace | - | Brighton & Hove Albion | 1:1 | ||||
| 7. Round | 02/10/2021 | Brighton & Hove Albion | - | Arsenal FC | 0:0 | ||||
| 8. Round | 16/10/2021 | Norwich City | - | Brighton & Hove Albion | 0:0 |  |
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| 9. Round | 23/10/2021 | Brighton & Hove Albion | - | Manchester City | 1:4 | ||||
| 15. Round | 04/12/2021 | Southampton FC | - | Brighton & Hove Albion | 1:1 | ||||
| 17. Round | 15/12/2021 | Brighton & Hove Albion | - | Wolverhampton Wanderers | 0:1 | |
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| 19. Round | 26/12/2021 | Brighton & Hove Albion | - | Brentford FC | 2:0 | ||||
| 20. Round | 29/12/2021 | Chelsea FC | - | Brighton & Hove Albion | 1:1 | ||||
| 21. Round | 02/01/2022 | Everton FC | - | Brighton & Hove Albion | 2:3 |  |
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| 22. Round | 14/01/2022 | Brighton & Hove Albion | - | Crystal Palace | 1:1 | ||||
| 24. Round | 18/01/2022 | Brighton & Hove Albion | - | Chelsea FC | 1:1 | |
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| 23. Round | 23/01/2022 | Leicester City | - | Brighton & Hove Albion | 1:1 | |
England
