| 1. Round | 05/08/2022 | Willem II | - | Jong PSV | 1:1 | ||||
| 2. Round | 12/08/2022 | FC Eindhoven | - | Willem II | 2:1 |  |
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| 3. Round | 19/08/2022 | Willem II | - | Telstar | 2:1 | ||||
| 4. Round | 29/08/2022 | FC Utrecht (J) | - | Willem II | 0:0 | ||||
| 5. Round | 02/09/2022 | Willem II | - | ADO Den Haag | 1:0 | ||||
| 6. Round | 09/09/2022 | PEC Zwolle | - | Willem II | 2:2 | |
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| 7. Round | 16/09/2022 | Willem II | - | AZ Alkmaar (J) | 1:0 | ||||
| 8. Round | 23/09/2022 | TOP Oss | - | Willem II | 1:3 | ||||
| 9. Round | 30/09/2022 | MVV | - | Willem II | 3:2 | ||||
| 10. Round | 07/10/2022 | Willem II | - | FC Den Bosch | 1:2 | ||||
| 11. Round | 14/10/2022 | Helmond Sport | - | Willem II | 1:3 | ||||
| 12. Round | 21/10/2022 | Willem II | - | Almere City FC | 1:1 | ||||
| 13. Round | 31/10/2022 | Jong Ajax | - | Willem II | 1:2 | ||||
| 14. Round | 04/11/2022 | Willem II | - | Heracles Almelo | 1:2 | ||||
| 15. Round | 11/11/2022 | VVV-Venlo | - | Willem II | 0:0 | ||||
| 17. Round | 11/12/2022 | Willem II | - | NAC Breda | 1:2 | ||||
| 18. Round | 16/12/2022 | De Graafschap | - | Willem II | 0:3 |
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