| 1. Round | 05/08/2022 | Fulham FC U21 | - | West Ham United U21 | 3:1 | ||||
| 2. Round | 12/08/2022 | West Ham United U21 | - | Arsenal FC U21 | 2:3 | ||||
| 3. Round | 19/08/2022 | Leicester City U21 | - | West Ham United U21 | 3:1 | ||||
| 16. Round | 20/01/2023 | West Ham United U21 | - | Manchester United U21 | 2:3 | ||||
| 17. Round | 27/01/2023 | Chelsea FC U21 | - | West Ham United U21 | 2:3 | ||||
| 18. Round | 10/02/2023 | West Ham United U21 | - | Fulham FC U21 | 1:0 | ||||
| 19. Round | 17/02/2023 | Arsenal FC U21 | - | West Ham United U21 | 1:1 | ||||
| 20. Round | 27/02/2023 | West Ham United U21 | - | Brighton & Hove Albion U21 | 3:2 | ||||
| 21. Round | 03/03/2023 | West Ham United U21 | - | Manchester City U21 | 1:5 | ||||
| 22. Round | 20/03/2023 | Wolverhampton Wanderers U21 | - | West Ham United U21 | 0:5 | ||||
| 23. Round | 01/04/2023 | West Ham United U21 | - | Blackburn Rovers U21 | 1:3 |  |
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| 24. Round | 17/04/2023 | Crystal Palace U21 | - | West Ham United U21 | 3:3 | ||||
| 25. Round | 22/04/2023 | Liverpool FC U21 | - | West Ham United U21 | 1:0 | ||||
| 26. Round | 28/04/2023 | West Ham United U21 | - | Leicester City U21 | 2:0 | ||||
| 15. Round | 07/05/2023 | Tottenham Hotspur U21 | - | West Ham United U21 | 1:0 |
England