| 11. Round | 09/10/2021 | Bristol Rovers | - | Carlisle United | 3:0 |  |
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| 17. Round | 20/11/2021 | Exeter City | - | Carlisle United | 2:1 | ||||
| 18. Round | 23/11/2021 | Carlisle United | - | Harrogate Town | 0:2 | ||||
| 20. Round | 07/12/2021 | Mansfield Town | - | Carlisle United | 1:0 | ||||
| 21. Round | 11/12/2021 | Stevenage FC | - | Carlisle United | 0:2 | ||||
| 25. Round | 01/01/2022 | Scunthorpe United | - | Carlisle United | 0:1 | ||||
| 31. Round | 08/02/2022 | Carlisle United | - | Port Vale FC | 1:3 | ||||
| 23. Round | 01/03/2022 | Carlisle United | - | Rochdale AFC | 2:0 | ||||
| 35. Round | 05/03/2022 | Oldham Athletic | - | Carlisle United | 1:2 | ||||
| 37. Round | 15/03/2022 | Carlisle United | - | Newport County | 1:2 | ||||
| 38. Round | 19/03/2022 | Barrow AFC | - | Carlisle United | 1:2 | ||||
| 39. Round | 26/03/2022 | Carlisle United | - | Bristol Rovers | 1:0 | ||||
| 30. Round | 29/03/2022 | Rochdale AFC | - | Carlisle United | 2:0 | |
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| 40. Round | 02/04/2022 | Tranmere Rovers | - | Carlisle United | 2:2 | ||||
| 41. Round | 09/04/2022 | Carlisle United | - | Exeter City | 0:1 | ||||
| 43. Round | 18/04/2022 | Carlisle United | - | Mansfield Town | 1:0 | ||||
| 44. Round | 23/04/2022 | Harrogate Town | - | Carlisle United | 3:0 | |
England