| 12. Round | 23/10/2021 | Barnet FC | - | Wrexham AFC | 0:3 | ||||
| 13. Round | 26/10/2021 | Maidenhead United | - | Wrexham AFC | 3:2 | ||||
| 14. Round | 30/10/2021 | Wrexham AFC | - | Torquay United | 1:1 | ||||
| 9. Round | 09/11/2021 | Aldershot Town | - | Wrexham AFC | 0:5 | ||||
| 15. Round | 13/11/2021 | King's Lynn | - | Wrexham AFC | 2:6 |  |
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| 16. Round | 20/11/2021 | Wrexham AFC | - | Wealdstone FC | 0:0 | ||||
| 17. Round | 23/11/2021 | Halifax Town | - | Wrexham AFC | 1:2 | ||||
| 18. Round | 27/11/2021 | Wrexham AFC | - | Bromley FC | 2:0 | ||||
| 30. Round | 19/02/2022 | Wealdstone FC | - | Wrexham AFC | 1:2 | ||||
| 31. Round | 22/02/2022 | Chesterfield FC | - | Wrexham AFC | 0:2 | ||||
| 37. Round | 26/03/2022 | Wrexham AFC | - | Dover Athletic | 6:5 | |
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| 34. Round | 05/04/2022 | Wrexham AFC | - | Barnet FC | 6:0 | ||||
| 39. Round | 09/04/2022 | Wrexham AFC | - | Eastleigh FC | 3:2 | ||||
| 41. Round | 18/04/2022 | Wrexham AFC | - | Altrincham FC | 4:0 | ||||
| 42. Round | 23/04/2022 | Woking FC | - | Wrexham AFC | 2:1 | ||||
| 44. Round | 02/05/2022 | Boreham Wood | - | Wrexham AFC | 1:1 | ||||
| 46. Round | 15/05/2022 | Dagenham & Redbridge | - | Wrexham AFC | 3:0 |
England