| 1. Round | 07/08/2010 | Southampton FC | - | Plymouth Argyle | 0:1 | ||||
| 3. Round | 21/08/2010 | Southampton FC | - | Leyton Orient | 1:1 | ||||
| 4. Round | 28/08/2010 | Bristol Rovers | - | Southampton FC | 0:4 | ||||
| 5. Round | 04/09/2010 | Southampton FC | - | Rochdale AFC | 0:2 | ||||
| 6. Round | 11/09/2010 | Swindon Town | - | Southampton FC | 1:0 | ||||
| 2. Round | 15/09/2010 | Milton Keynes Dons | - | Southampton FC | 2:0 | ||||
| 17. Round | 20/11/2010 | Southampton FC | - | Peterborough United | 4:1 | ||||
| 20. Round | 11/12/2010 | Southampton FC | - | Brentford FC | 0:2 | ||||
| 29. Round | 05/04/2011 | Southampton FC | - | Charlton Athletic | 2:0 | ||||
| 42. Round | 16/04/2011 | Southampton FC | - | Bristol Rovers | 1:0 | ||||
| 43. Round | 23/04/2011 | Brighton & Hove Albion | - | Southampton FC | 1:2 |  |
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| 44. Round | 25/04/2011 | Southampton FC | - | Hartlepool United | 2:0 | ||||
| 45. Round | 30/04/2011 | Brentford FC | - | Southampton FC | 0:3 | |
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| 39. Round | 02/05/2011 | Plymouth Argyle | - | Southampton FC | 1:3 | ||||
| 46. Round | 07/05/2011 | Southampton FC | - | Walsall FC | 3:1 | |
Ireland