| 1. Round | 06/08/2005 | Southampton FC | - | Wolverhampton Wanderers | 0:0 | ||||
| 2. Round | 09/08/2005 | Luton Town | - | Southampton FC | 3:2 | ||||
| 3. Round | 13/08/2005 | Sheffield Wednesday | - | Southampton FC | 0:1 | ||||
| 4. Round | 20/08/2005 | Southampton FC | - | Norwich City | 1:0 | ||||
| 5. Round | 27/08/2005 | Southampton FC | - | Crewe Alexandra | 2:0 | ||||
| 6. Round | 29/08/2005 | Coventry City | - | Southampton FC | 1:1 |  |
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| 7. Round | 10/09/2005 | Southampton FC | - | Queens Park Rangers | 1:1 | ||||
| 22. Round | 03/12/2005 | Southampton FC | - | Burnley FC | 1:1 | ||||
| 23. Round | 11/12/2005 | Southampton FC | - | Luton Town | 1:0 | ||||
| 24. Round | 17/12/2005 | Norwich City | - | Southampton FC | 3:1 | ||||
| 25. Round | 26/12/2005 | Watford FC | - | Southampton FC | 3:0 | ||||
| 27. Round | 31/12/2005 | Cardiff City | - | Southampton FC | 2:1 | ||||
| 28. Round | 02/01/2006 | Southampton FC | - | Brighton & Hove Albion | 2:1 | ||||
| 29. Round | 14/01/2006 | Queens Park Rangers | - | Southampton FC | 1:0 | ||||
| 30. Round | 21/01/2006 | Southampton FC | - | Ipswich Town | 0:2 | ||||
| 17. Round | 25/01/2006 | Southampton FC | - | Crystal Palace | 0:0 | |
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| 46. Round | 30/04/2006 | Southampton FC | - | Leicester City | 2:0 |
England
