| 1. Round | 07/08/2021 | Stoke City | - | Reading FC | 3:2 | ||||
| 5. Round | 28/08/2021 | Huddersfield Town | - | Reading FC | 4:0 | ||||
| 7. Round | 14/09/2021 | Reading FC | - | Peterborough United | 3:1 | ||||
| 8. Round | 18/09/2021 | Fulham FC | - | Reading FC | 1:2 | ||||
| 9. Round | 25/09/2021 | Reading FC | - | Middlesbrough FC | 1:0 |  |
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| 10. Round | 29/09/2021 | Derby County | - | Reading FC | 1:0 | ||||
| 21. Round | 04/12/2021 | Reading FC | - | Hull City | 1:1 | ||||
| 22. Round | 11/12/2021 | West Bromwich Albion | - | Reading FC | 1:0 | |
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| 25. Round | 11/01/2022 | Reading FC | - | Fulham FC | 0:7 | ||||
| 27. Round | 15/01/2022 | Middlesbrough FC | - | Reading FC | 2:1 |
England