| 30. Round | 31/01/2022 | Portsmouth FC | - | Charlton Athletic | 1:2 | ||||
| 31. Round | 05/02/2022 | Oxford United | - | Portsmouth FC | 3:2 |  |
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| 32. Round | 08/02/2022 | Portsmouth FC | - | Burton Albion | 2:1 | ||||
| 35. Round | 22/02/2022 | Shrewsbury Town | - | Portsmouth FC | 1:2 |  |
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| 36. Round | 26/02/2022 | Portsmouth FC | - | Fleetwood Town | 3:3 | ||||
| 24. Round | 01/03/2022 | Portsmouth FC | - | Oxford United | 3:2 | ||||
| 34. Round | 08/03/2022 | Crewe Alexandra | - | Portsmouth FC | 1:3 | ||||
| 38. Round | 12/03/2022 | Ipswich Town | - | Portsmouth FC | 0:0 | ||||
| 25. Round | 15/03/2022 | Plymouth Argyle | - | Portsmouth FC | 1:0 |
England