| 1. Round | 14/08/2021 | Sunderland AFC [U18] | - | Wolverhampton Wanderers [U18] | 0:1 | ||||
| 2. Round | 21/08/2021 | Wolverhampton Wanderers [U18] | - | Newcastle United [U18] | 2:2 | ||||
| 3. Round | 28/08/2021 | Blackburn Rovers [U18] | - | Wolverhampton Wanderers [U18] | 5:2 | ||||
| 4. Round | 11/09/2021 | Wolverhampton Wanderers [U18] | - | Manchester City [U18] | 2:1 | ||||
| 5. Round | 25/09/2021 | Everton FC [U18] | - | Wolverhampton Wanderers [U18] | 2:1 | ||||
| 12. Round | 18/12/2021 | Stoke City [U18] | - | Wolverhampton Wanderers [U18] | 0:4 | ||||
| 14. Round | 27/01/2022 | Wolverhampton Wanderers [U18] | - | Middlesbrough FC [U18] | 2:0 | ||||
| 17. Round | 19/02/2022 | Liverpool FC [U18] | - | Wolverhampton Wanderers [U18] | 2:1 | ||||
| 15. Round | 29/03/2022 | Nottingham Forest [U18] | - | Wolverhampton Wanderers [U18] | 1:1 |
England