| 1. Round | 16/08/2021 | Tottenham Hotspur U23 | - | Chelsea FC U23 | 2:2 |  |
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| 2. Round | 23/08/2021 | Leeds United U23 | - | Tottenham Hotspur U23 | 2:4 | |
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| 3. Round | 27/08/2021 | Tottenham Hotspur U23 | - | Arsenal FC U23 | 1:2 | ||||
| 5. Round | 17/09/2021 | Blackburn Rovers U23 | - | Tottenham Hotspur U23 | 3:3 |  |
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| 6. Round | 27/09/2021 | Tottenham Hotspur U23 | - | Derby County U23 | 3:1 | |
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| 7. Round | 01/10/2021 | Crystal Palace U23 | - | Tottenham Hotspur U23 | 4:3 | |
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| 8. Round | 18/10/2021 | Tottenham Hotspur U23 | - | West Ham United U23 | 3:4 | ||||
| 9. Round | 23/10/2021 | Manchester City U23 | - | Tottenham Hotspur U23 | 1:3 | |
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| 10. Round | 30/10/2021 | Tottenham Hotspur U23 | - | Manchester United U23 | 1:0 | |
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| 11. Round | 05/11/2021 | Brighton & Hove Albion U23 | - | Tottenham Hotspur U23 | 1:1 | |
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| 12. Round | 22/11/2021 | Leicester City U23 | - | Tottenham Hotspur U23 | 1:4 | ||||
| 13. Round | 26/11/2021 | Tottenham Hotspur U23 | - | Everton FC U23 | 4:0 | |
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| 14. Round | 04/12/2021 | Tottenham Hotspur U23 | - | Manchester City U23 | 3:0 | |
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| 16. Round | 10/01/2022 | Manchester United U23 | - | Tottenham Hotspur U23 | 1:1 | |
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England
India