| 17. Round | 16/02/2021 | Brighton & Hove Albion [U18] | - | Southampton FC [U18] | 7:1 | ||||
| 18. Round | 20/02/2021 | Leicester City [U18] | - | Southampton FC [U18] | 1:0 | ||||
| 20. Round | 13/03/2021 | Fulham FC [U18] | - | Southampton FC [U18] | 6:0 | ||||
| 22. Round | 10/04/2021 | Southampton FC [U18] | - | Tottenham Hotspur [U18] | 0:3 | ||||
| 25. Round | 01/05/2021 | West Ham United [U18] | - | Southampton FC [U18] | 3:2 | ||||
| 26. Round | 08/05/2021 | Southampton FC [U18] | - | Reading FC [U18] | 6:4 |  |
England