| 13. Round | 16/10/2021 | Doncaster Rovers | - | Wycombe Wanderers | 0:2 | ||||
| 14. Round | 19/10/2021 | Rotherham United | - | Wycombe Wanderers | 0:0 | ||||
| 15. Round | 23/10/2021 | Wycombe Wanderers | - | Crewe Alexandra | 2:1 | ||||
| 6. Round | 02/11/2021 | Wycombe Wanderers | - | Ipswich Town | 1:4 | ||||
| 35. Round | 22/02/2022 | Wycombe Wanderers | - | Wigan Athletic | 1:3 | ||||
| 36. Round | 26/02/2022 | Accrington Stanley | - | Wycombe Wanderers | 3:2 |  |
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| 43. Round | 15/04/2022 | Wycombe Wanderers | - | Plymouth Argyle | 2:0 | ||||
| 44. Round | 18/04/2022 | AFC Wimbledon | - | Wycombe Wanderers | 1:1 | ||||
| 45. Round | 23/04/2022 | Wycombe Wanderers | - | Sheffield Wednesday | 1:0 | ||||
| 46. Round | 30/04/2022 | Burton Albion | - | Wycombe Wanderers | 1:2 |
England