| 1. Round | 04/09/2021 | Tottenham Hotspur WFC [Women] | - | Birmingham City WFC [Women] | 1:0 | ||||
| 2. Round | 12/09/2021 | Birmingham City WFC [Women] | - | Brighton & Hove Albion WFC [Women] | 0:5 | ||||
| 3. Round | 25/09/2021 | Everton FC [Women] | - | Birmingham City WFC [Women] | 3:1 | ||||
| 4. Round | 03/10/2021 | Birmingham City WFC [Women] | - | Manchester United WFC [Women] | 0:2 | ||||
| 5. Round | 10/10/2021 | West Ham United WFC [Women] | - | Birmingham City WFC [Women] | 1:1 | ||||
| 6. Round | 07/11/2021 | Birmingham City WFC [Women] | - | Reading WFC [Women] | 0:3 | ||||
| 10. Round | 19/12/2021 | Leicester City WFC [Women] | - | Birmingham City WFC [Women] | 2:0 | ||||
| 12. Round | 15/01/2022 | Manchester United WFC [Women] | - | Birmingham City WFC [Women] | 5:0 | ||||
| 13. Round | 23/01/2022 | Reading WFC [Women] | - | Birmingham City WFC [Women] | 3:2 | ||||
| 16. Round | 06/03/2022 | Arsenal WFC [Women] | - | Birmingham City WFC [Women] | 4:2 | ||||
| 17. Round | 13/03/2022 | Birmingham City WFC [Women] | - | West Ham United WFC [Women] | 0:1 | ||||
| 19. Round | 01/04/2022 | Birmingham City WFC [Women] | - | Everton FC [Women] | 0:0 |
Ireland