6. Round | 27/09/2021 | Birmingham City U23 | - | Southampton FC U23 | 3:2 | ||||
7. Round | 01/10/2021 | Southampton FC U23 | - | Stoke City U23 | 1:1 | ||||
9. Round | 25/10/2021 | Reading FC U23 | - | Southampton FC U23 | 0:1 | ||||
10. Round | 31/10/2021 | Southampton FC U23 | - | Aston Villa U23 | 4:0 | ||||
11. Round | 05/11/2021 | Southampton FC U23 | - | Newcastle United U23 | 5:0 | ||||
17. Round | 17/01/2022 | Southampton FC U23 | - | Fulham FC U23 | 2:1 | ||||
18. Round | 23/01/2022 | Southampton FC U23 | - | Middlesbrough FC U23 | 1:0 | ||||
19. Round | 07/02/2022 | West Bromwich Albion U23 | - | Southampton FC U23 | 0:1 | ||||
20. Round | 21/02/2022 | Southampton FC U23 | - | Birmingham City U23 | 2:3 | ||||
21. Round | 26/02/2022 | Southampton FC U23 | - | Nottingham Forest U23 | 4:2 | ||||
22. Round | 11/03/2022 | Aston Villa U23 | - | Southampton FC U23 | 2:2 | ||||
23. Round | 20/03/2022 | Southampton FC U23 | - | Reading FC U23 | 2:1 | ||||
16. Round | 25/03/2022 | Southampton FC U23 | - | Wolverhampton Wanderers U23 | 2:4 | ||||
24. Round | 02/04/2022 | Burnley FC U23 | - | Southampton FC U23 | 2:1 |